Posted by zeugma on August 6, 2004, at 7:10:36
In reply to Re: Why these meds don't work, posted by LastDyingWish on August 5, 2004, at 19:20:38
Buspar is on-point, it is a partial agonist at the 5-HT 1A receptor, which modulates serotonin release. Supposedly, if levels are too low, it will raise them, or if too high, it will lower them. I have read that long-term use (>8 weeks) desensitizes this receptor, leading to stronger serotonin release.
The strange thing about Buspar is that it was marketed as an anxiolytic, not as an antidepressant. I have sometimes wondered that if Buspar had received the same hype that the SSRI's did, it would be considered as strong an AD as Lexapro, Paxil etc. Its close relative gepirone was due for approval a few weeks ago, but failed to get it from the FDA. It was to be marketed as an antidepressant.
poster:zeugma
thread:374460
URL: http://www.dr-bob.org/babble/20040805/msgs/374610.html