Posted by Ame Sans Vie on August 6, 2004, at 14:32:04
In reply to On second thought. . ., posted by sb417 on August 5, 2004, at 23:38:08
Thanks so much for your input! I'm glad to hear that someone here has heard of the bupropion + amphetamine combination. I am sorry to hear about that fatality you mentioned though... but as you mentioned, my ability to withstand even the most robust polypharmacy without incidence will most likely preclude me from being exposed to that type of danger. Also, I make extra sure to never take more than my prescribed 120mg of Adderall daily, and I am hoping that may decrease to 80mg or so (20mg QID) with the addition of Wellbutrin XL.
I've always very well tolerated interactions mediated by CYPIID6, so (thank God) that shouldn't be an issue. Though I understand there is some dispute in the scientific community as to the extent of bupropion's IID6 inhibition (i.e., some say it is a quite mild inhibitor, some put it at the higher end of the "moderate inhibition" scale). But, as you said, if I was able to tolerate a very powerful inhibitor such as fluoxetine so well, bupropion certainly shouldn't pose a problem in that regard. As far as the dextromethorphan is concerned, my doctor has consulted with colleagues at the University of Houston and they've come to the unanimous conclusion that the low dose I'm taking bears little chance of interfering. Besides, if it weren't for the DXM HBr, I'm sure I'd be taking upwards of 300mg Adderall per day by now! :-O (btw, I use the Adderall primarily as an antidepressant)
Again, thanks a bunch for the thorough analysis of my prospective meds!
All the best,
~Michael
poster:Ame Sans Vie
thread:374353
URL: http://www.dr-bob.org/babble/20040805/msgs/374747.html