Posted by don_bristol on August 9, 2004, at 6:44:41
I am concerned about my blood pressure rising if I mistakenly eat some food which has some tyramine in it.
Is it better to take an MAOI *AFTER* a meal or eating some food in order to minimise the blood pressure rise?
I came across this info (below) for Moclobemide. Admittedly Moclobemide is a "reversible" inhibitor of MAO unlike Nardil or Parnate but I would guess the findings might still apply.
Does anyone have any info or thoughts about this?
<QUOTE>
Drug Interactions: Tyramine:During studies conducted at the maximum recommended moclobemide dose of 600 mg/day, the mean dose of tyramine required to produce a 30 mm Hg increase in systolic blood pressure was 148 +/- 50 mg ( 76 to 200 mg) when moclobemide was administered immediately after tyramine. The threshold dose of tyramine was reduced to 84 +/- 23 mg (54 to 112 mg) when the sequence of administration was reversed so that moclobemide was administered 1 hour before tyramine. These findings indicate that the potentiation of tyramine may be minimized by administering moclobemide after, instead of prior to, a tyramine-enriched meal.
<END QUOTE>
from http://www.mentalhealth.com/drug/p30-m04.htmlDon
poster:don_bristol
thread:375534
URL: http://www.dr-bob.org/babble/20040805/msgs/375534.html