Posted by Ame Sans Vie on August 12, 2004, at 20:51:02
In reply to Re: Somebody! I need advice fast! » Ame Sans Vie, posted by Sad Panda on August 12, 2004, at 18:01:53
> Hi Michael,
>
> I like Nort myself & I find it anxiolytic. Desipramine is a potent NE reuptake inhibitor with the least side effects of any TCA. Nortriptyline is also a potent NE reuptake inhibitor, but it's toned down because it adds 5-HT2A antagonism which can be anxiolytic & does improve sleep & counters most SSRI side effects, downside is it does have more A1 & M1 blockade than Desipramine, it also is a modest H1 blocker.Thanks a bunch for your opinion! So, from what you've said I'm drawing the conclusion that you've tried both desipramine and nortriptyline... could I trouble you to go any deeper into the subjective differences between the two drugs? What *did* each help with?...What *didn't* each help? Sorry, I'm just really wanting to become very knowledge on this subject in case the time comes again that I must weigh nortriptyline as an option.
My pdoc became ill and had to leave the office, so he referred me to a general practitioner friend of his. I figured I'd just go for the desipramine (and *why* I'll explain in a moment <g>) and so she wrote up a script for 180 x 100mg tablets, with one refill, lol (talk about overkill -- thank goodness I haven't experienced suicidal ideation in several years). But hey, if it works well at least I have plenty on hand. About six months plenty to be exact, lol.
~Why I went with desipramine:
I am constantly coming across the following quote in various places on the web, and it has me intrigued. Maybe I'll be able to cut back on the Adderall? ....
"Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated."
I had taken 30mg Adderall two hours prior to taking my first two desipramine; the peak of the drug's effect was waning, but within fifteen minutes of taking the desipramine, I felt that nice amphetamine "kick" all over again. I'm *definitely* going to try decreasing my dose of Adderall to 15 or 20mg four times daily starting tomorrow.
~Michael
poster:Ame Sans Vie
thread:376819
URL: http://www.dr-bob.org/babble/20040811/msgs/377019.html