Posted by don_bristol on August 13, 2004, at 13:12:23
In reply to Re: Parnate RAISES my blood pressure (without food) !, posted by King Vultan on August 11, 2004, at 12:22:44
Todd wrote:
>> Keep in mind that the Parnate is really two drugs in one--a stimulant + an MAOI--and they do have different effects. <<
Todd, I thought that Parnate's stimulant action came from Parnate being an MAOI. Of course other MAOI's (like Nardil) do not act as a stimulant. But I thought that Parnate was only an MAOI. Can you say more about the stimulant action of Parnate please?I recently looked into Medline for "tranylcypromine and amphetamine" and saw there had been some debate about what exactly did happen to parnate when it was metabolised. But I found the entries were inconclusive - probably because I did not have a big picture of what the debate had concluded.
This 1999 entry says "There is considerable debate about whether or not it is metabolized to amphetamine, with most of studies in the literature indicating that this does not occur." http://tinyurl.com/5c8pm
And this entry http://tinyurl.com/6y4uv asks "Is tranylcypromine really metabolized to amphetamine?" but no text is given.
Also " This lends strong evidence against amphetamine being a metabolite of tranylcypromine"
http://tinyurl.com/5tjg3Thanks for any further info.
poster:don_bristol
thread:376369
URL: http://www.dr-bob.org/babble/20040811/msgs/377219.html