Posted by Sad Panda on August 23, 2004, at 23:56:33
In reply to Nardil + Nortriptyline - urgent qstns!!!, posted by ace on August 23, 2004, at 18:51:05
> In my never ending quest to rid myself of OCD, me and my doctor have agreed to give Nortriptyline a go. We have both seen some clinical trials wher Nortyptiline has been added to Anafranil, thus squashing OCD. I have a few qstns kids....
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> 1. With Nardil- Suggestions have been made that it can safely be added concurrently with the Nardil....or should I lower right down to 15mg, skip a day, then start Nortryptyline, and the next day back to Nardil??
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> 2. reboxetine (another NE booster) caused me depression...obv\iously there is major differences between Nortryptyline and rebox, but can anyone forsee another return of depression.
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> 3. Dosage...My doc, and I agree, believes the main problem with TCA's is dosage...most people have their dosage too LOW. does 60mg Nardil + 75mg Nortryptiline seem adequate?
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> 4. Anyone with experience of this drug, for anything, please give me all details!!!!!!
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> Thanks so much dudes and dudettes!!!
>
> Ace!
>Hi Ace,
1. Do you know which P450 enzyme metabolises Nardil? I know that Nardil inhibits it's own metabolisim & Nortriptyline uses 2D6. If there is no clash, I would leave the Nardil doseage alone. Nort is a weak SRI, I don't think this would be a problem. Hyperthermia is the deadly part of serotonin syndrome, taking a 5-HT2A antagonist counters this, so extra Zyprexa would be good as an antidote if you suspect SS, discuss it with your doctor of course. Nort is a moderate 5-HT2A antagonist too, so it's kind of self protecting.
2. I don't know.
3. I just had my first Nort plasma level today. I am currently at 125mg, guess I will find out in a couple of days what my plasma level is.
4. I had transient headaches & impotence when I started it, the headaches lasted a few days, the impotence lasted a couple of weeks. Start Nort with the doseages spread a bit, but later you can take it all in one hit because it has an average half life of 36 hours, YMMW of course. Nort might lower your BP & is likely to cause you some orthostatic hypotension, but it hasn't for me. (I am obese with high blood pressure). It will slow your bowel down, which is good for me & one of the reasons I went for Nort instead of Rebox.
Cheers,
Panda.
poster:Sad Panda
thread:381471
URL: http://www.dr-bob.org/babble/20040821/msgs/381576.html