Posted by Dave001 on August 24, 2004, at 17:29:02
In reply to Re: is Ritalin neurotoxic?, posted by Shawn. T. on August 24, 2004, at 5:41:59
> Dopamine- induced neurotoxicity is primarily a result of the oxidation of free intracellular dopamine.
While there is little doubt that increased levels of ROS are present in many (most?) degenerative diseases, I'm curious how you arrived at this conclusion. Could you please elaborate on the process immediately preceding the oxidation of the free intracellular dopamine that you propose, leading up to the damage of DA neurons?
Also, how would you explain that animals with depletions of brain DA appear equally vulnerable to the neurotoxicity of amphetamines? [1,2]
Dave
1. Albers DS and Sonsalla PK (1995) Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents. J Pharmacol Exp Ther 275: 1104-1114
2. Wagner GC, Lucot JB, Schuster CR and Seiden LS (1983) Alpha-Methyltyrosine attenuates and reserpine increases methamphetamine-induced neuronal changes. Brain Res 270: 285
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poster:Dave001
thread:380741
URL: http://www.dr-bob.org/babble/20040821/msgs/381830.html