Posted by Philidor on August 26, 2004, at 11:12:47
Sorry to harp on this subject again, but it is important. It recently dawned on me that many posters (me included) have been barking up the wrong tree on this!
All this speculating on neuroreceptors, agonists, dopamine depletion etc., etc., may be missing the point entirely, by focusing on the brain, when the real problem is in the GUT!
How the drug is taken makes a big difference, because there are at least three different ways by which tolerance can develop.
Drugs that are swallowed (like Adderall) may no longer even make it to the brain after a time because the liver thinks they are toxins and starts to release enzymes to neutralize them. Metabolic tolerance. (Check out Question 2):
http://abdellab.sunderland.ac.uk/Lectures/pcl312_exam2004.html
This is just the reason people trying to get high shoot or snort or smoke their stuff instead of swallowing it. To bypass that roadblock.
Phil
poster:Philidor
thread:382536
URL: http://www.dr-bob.org/babble/20040825/msgs/382536.html