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Re: TCA to help with Effexor discontinuation symptoms?

Posted by King Vultan on September 10, 2004, at 16:00:53

In reply to TCA to help with Effexor discontinuation symptoms?, posted by Colleen D. on September 10, 2004, at 14:47:22

> Can being on a TCA (in my case, Doxepin) as a sleep aid help with "withdrawal" from Effexor?
>
> I may be changing meds in a few weeks and I wonder if I continue with 50mg doxepin each night for sleep I might have a better chance of avoiding some of the physical problems many people seem to have when tapering off Effexor??? Don't they affect the same neurotransmitters? Or is the doxepin likely to have little effect because the dose is so small and/or it wouldn't stay in my system long enough to make any difference? Maybe I should take a larger dose during that time?
>
> Thanks!
>
> Colleen

My guess is that the doxepin is so weak at blocking serotonin reuptake that it probably isn't going to do much good. Looking at the value of the dissociation constant for doxepin blocking serotonin reuptake all by itself, it might make it look like it's doing something there, but my opinion is that its histamine blockade is so overwhelmingly powerful in comparison that this is going to dominate the character of the drug, particularly at lower dosages.

Todd


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poster:King Vultan thread:389263
URL: http://www.dr-bob.org/babble/20040909/msgs/389292.html