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Re: where are the diagnostic tests?!! » zeugma

Posted by SLS on September 14, 2004, at 17:53:25

In reply to Re: where are the diagnostic tests?!!, posted by zeugma on September 14, 2004, at 17:28:19

Hi Z.

> You don't think that the concepts of melancholia and atypical depression are valid subtypes?

I definitely do.

> There's an interesting paper written by Quitkin

I was one of Quitkin's early subjects when he began to study this issue in the early 1980s.

> it's remarkable that after 50 years, these theoretical constructs are still being played around with.

Quitkin has been resting on the laurels of his work by repeating it over and over.

> in any case understanding the individual's unique circuitry would appear to be a staggering task,

Maybe not so much. I don't know. I think it is a question of choosing the right biological probes or drugs to challenge the system with, and then seeing which areas of the brain, if any, light up in a PET scan or fMRI. It would be more empirical than deductive. This might be further improved perhaps by having the subject perform certain tasks while being exposed to the probe to better resolve regional or circuit activities.


> I'm also feeling a little frustrated that nortriptyline appears to be the only psychotropic that doesn't damage my circuitry somewhere,

Damage in what way? How can you tell?

> although it does not treat all my symptoms and so is acquiring quite a stable of fellow passengers in my bloodstream.

What are your thoughts about trying Cymbalta? I can't think of any reason why you couldn't combine it with nortriptyline.

- Scott

 

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