Posted by alesta on September 15, 2004, at 17:41:48
In reply to Re: GAD/Dysthymia/Smoking: Buspar (or Cymbalta or ...? » alesta, posted by cache-monkey on September 15, 2004, at 15:22:15
hey, c-m,:)
> It turns out that Prozac is a little different than the other SSRIs in terms of how it affects dopamine and norepinephrine. According to another study published in Psychopharmacology (link to abstract below):
> "Fluoxetine, citalopram, fluvoxamine, paroxetine and sertraline similarly increased the extracellular concentrations of serotonin from 2- to 4-fold above baseline. However, only fluoxetine produced robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. ... Amongst the SSRIs examined, only fluoxetine acutely increases extracellular concentrations of norepinephrine and dopamine as well as serotonin in prefrontal cortex, suggesting that fluoxetine is an atypical SSRI."
> [ Abstract at
> http://www.biopsychiatry.com/fluoxdopnor.htm ]
>
> Of course, this study (as well as the one I mentioned earlier) was undertaken using rats rather than humans. The in vivo properties might be different for humans...interesting. i've taken prozac and can tell you from personal experience that my dopamine levels dropped drastically..i experienced all the symptoms i mentioned..anhedonia, akathesia, sexual side effects, etc. these side effects were extreme and pronounced for me and very unpleasant..i do wonder about some of these studies..hmm..but thanks for sharing.:)
> Oh, I wasn't trying to imply that anyone was suggesting I do something drastic. I guess that for me I have some apprehension with respect going on Cymbalta. So, even though I mentioned it as something I'm considering, I still see it as a little bit more drastic than upping the BuSpar.sorry..:)..i'm a bit oversensitive right now due to catastrophic life events:) i didn't mean to get attitudinal on you.:):)..i wish you luck!
take care,:)
amy
poster:alesta
thread:390925
URL: http://www.dr-bob.org/babble/20040915/msgs/391183.html