Posted by karaS on September 28, 2004, at 15:12:42
In reply to Re: Cymbalta and REM sleep - dreaming? » karaS, posted by zeugma on September 28, 2004, at 4:26:36
> How do you see an SNRI like Cymbalta fitting in here? Just as much potential for those "ominous long-term side effects" or could the addition of NE change things? If I'm interpreting what you wrote above correctly, then it can only make things worse, no?
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> Kara
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> Kara,
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> I think that probably the addition of noradrenergic effects helps the dopaminergic side of things because norepinephrine and dopamine are closely related (NE is one of the building blocks of dopamine). Imipramine, amitriptyline and clomipramine are dual reuptake inhibitors and have been around for many years without producing reports of REM behavior sleep disorder. Although admittedly I am less sure about clomipramine- it may be one of the 'serotonergetic AD's' referred to in the abstract. But if I had to guess, I would say that Cymbalta's dual reuptake inhibition helps to maintain the balance of monoamines in the brain.
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> -z
Thanks, zThat's what I would have thought (and hoped). I think I just misinterpreted something you said in your previous post which made me question it.
-K
poster:karaS
thread:395372
URL: http://www.dr-bob.org/babble/20040927/msgs/396398.html