Posted by zuzu80 on October 5, 2004, at 12:09:36
In reply to Difference between MAO-A and MAO-B? which drugs?, posted by ravenstorm on October 5, 2004, at 11:17:52
I would think that parnate would also affect dopamine. MAOI (Monoamine Oxidase Inhibitors) work usually unselectively ie they inhibit both MAO-A and MAO-B. MAO-A inhibits the degradation of Serotonin, Noradrenaline and Dopamine in the Central Nervous System (esp in neurons). Parnate as well as Nardil and others would thus affect the 3 neurotransmitters. Selegiline at low doses 5-10mg is selective and affects mainly dopamine (by mainly inhibiting MAO-B) but at higher doses it becomes non selective and affects the three monoamines.
This last point about selegeline has became doubted recently. MAO-B appears to reside mainly in glaial cells rather than neurons, and researchers think that dopamine in the neurons gets degraded by MAO-A. However, me and many others who took it at low doses notice the increased energy and motivation so researchers think that it has a clinical effect even if it only increases dopamine in the glial cells (the cells that support neurons). Selegiline is thought to increase the output potential of catecholamine (NA and DA) neurons since it gets metabolized in the liver to amphetamine and methamphetamine.
poster:zuzu80
thread:399167
URL: http://www.dr-bob.org/babble/20041002/msgs/399195.html