Posted by ed_uk on October 23, 2004, at 17:49:21
In reply to Re: Strattera with an MAOI? Any experiences?, posted by Ilene on October 22, 2004, at 11:30:03
The data sheet for all MAOIs states that they should not be used with tricyclics,including desipramine. Nevertheless, desipramine would be expected to be safer to combine with MAOIs than most other TCAs because it is a selective noradrenaline reuptake inhibitor. The most serious effect of combining an MAOI with a TCA is the serotonin syndrome-but since desipramine has no significant effect on serotonin reuptake this would be very unlikely with desipramine. Even so, combining almost any antidepresants has the potential to be dangerous, serotonin syndrome is not the only risk eg. seizures have been reported when people have recieved AD combinations.
Ed
poster:ed_uk
thread:405381
URL: http://www.dr-bob.org/babble/20041018/msgs/406436.html