Posted by Ritch on October 26, 2004, at 13:38:08
In reply to Re: topamax and pregabalin for social anxiety, posted by jonh kimble on October 26, 2004, at 11:07:54
> There are at least two studies which have been done recently, and while they were small scale, they showed very significant, if not more so than ssri's, improvement of generalised social anxiety in NON SSRI RESPONDERS with topamax, something I think is very interesting. and even in the benzo maoi range of 60 to 70% response rates. Pregabalin has also had similar results from what Ive seen. While neither is approved for this, I think they would be well worth checking out if ssri's failed. (Sorry in a hurry but the studies arent to terribly hard to find if i remeber) Ill come back to this if you would like. Tom
I was on a trial of Topamax (25mg 2x daily) in the past (as a Depakote replacement) and I must admit that it did have a very pronounced anxiolytic effect and great sleep. I just got really bad daytime somnolence from the Topamax and the duh's that were so bad it interfered with my job too much. If the half-life were quite a bit shorter (say 6 hrs instead of 24) I would probably still be taking 15mg of Topamax at bedtime as a sleeper (along with the Depakote I take now-perhaps without needing the clonazepam). I read somewhere that Depakote's mechanism of action is not only to be inhibition of GABA metabolism (kind of a GABA MAOI), but has a lot to do with the NMDA receptor. So does Topamax. So does Lamictal. Hmmm. The 15mg capsule is in "sprinkle" form. Maybe I could try a partial capsule at bedtime for sleep without making me a zombie the next day? Thanks for that information.
poster:Ritch
thread:407372
URL: http://www.dr-bob.org/babble/20041024/msgs/407493.html