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Re: social anxiety -dopamine/NA

Posted by King Vultan on October 29, 2004, at 8:01:12

In reply to social anxiety -dopamine/NA, posted by sabre on October 29, 2004, at 1:47:32

> Hello
> A few studies I have looked at mention that deficiencies of dopamine and NA may be implicated in social anxiety.
>
> If this is so, why aren't more people helped by Wellbutrin? Or do some people use it successfully for this problem?
>
> Some posts discuss that it causes heightened anxiety. If you took it with a benzo for a while, can you get through this phase or doesn't the agitation go away?
>
> Does it affect the git system?
>
> Is its anxiety provoking nature dose dependant?
> Thanks
> sabre

The dopamine effects are possibly part of the explanation why the nonselective MAOIs (Nardil and Parnate) are felt to be so good for social anxiety, but it could also be related to some other aspect of inhibiting MAO-B. I've also read posts from people saying that drugs like Adderall helped them quite a bit for their social anxiety. Wellbutrin may not be quite powerful enough, but I did notice it made me more somewhat bolder and more assertive, if nothing else.

Norepinephrine effects may also play a role in social anxiety, particularly for people like myself who have elements of panic disorder involved or mixed in. Increasing serotonin is also likely helpful in social anxiety, and that is why the SSRIs show the efficacy they do. Considering these different factors together, it's easy to see why the traditional MAOIs seem to be relatively good drugs for social anxiety/phobia.

Todd


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