Posted by KaraS on November 4, 2004, at 15:39:53
In reply to Re: Wellbutrin + Paxil? » KaraS, posted by SLS on November 4, 2004, at 6:17:19
> Hi Kara.
>
> Wellbutrin (bupropion) itself is increased by the inhibition of 2B6 by Paxil (not 2D6). Wellbutrin is a weak inhibitor of 2D6, but not a substrate. As Todd indicates, the major metabolite of Wellbutrin, 2-hydroxybupropion is affected by Paxil. It is increased due to the action of Paxil at both 2D6 and 2B6. It is pharmacology active, and thought by some as being more responsible than the parent compound for the therapeutic effect of Wellbutrin. Unfortunately, the seizure risk of Wellbutrin, although generally exaggerated, must still be taken into consideration. I was fine at a dosage of 900mg.
>
> Effexor + Wellbutrin is without these interactions and will not result in increased levels of either drug.
>
> Do you obtain a partial response to either Paxil or Effexor?
>
>
> - Scott
Thanks, Scott. This info was for a friend of mine on Wellbutrin. He is responding partially to it (perhaps as much as 50%). I'm trying to convince him to augment it rather than give up and try an SSRI - esp. since he has an anergic depression. He also has problems with GAD. My friend has not tried Effexor yet. He tried Paxil in the past but for many reasons thinks that he didn't give it an adequate trial. I hope he doesn't quit the Wellbutrin and try Paxil again.Kara
poster:KaraS
thread:411372
URL: http://www.dr-bob.org/babble/20041103/msgs/411780.html