Posted by jasmineneroli on November 22, 2004, at 0:30:19
In reply to Re: How do I know IF I am a slow metabolizer? » jasmineneroli, posted by Larry Hoover on November 21, 2004, at 9:01:25
Thanks V. much for the info, Lar.
Ha! it must've been a shock to come back to Babble and find all this waiting for you???
Anyway, in regard to myself, I've had another
a-ha moment. I discovered that the drug I had the stongest s/e reaction to (Moclobemide) is also a 2C19. That is the common denominator in my 3 worst drug reactions (all with the same symptoms). Now I know I can never take any drug that uses that enzyme in hepatic metabolism.
That is hugely helpful! I don't really care if I'm just a slow metabolizer or I simply don't have the enzyme present. I will avoid all 2C19 drugs!
I'm trying to search for info on tryptophan, but only find the hepatic enzyme named tryptophan pyrrolase, which is an enzyme specific to tryptophan and not part of the P450 clan! I will keep looking. I suspect P450 is not involved at all. The reason why I'm wondering about tryptophan is I've been feeling "unwell" lately and wonder, if this is culprit. Sleep and mood have improved, so I hope it's something else!
Thanks for being you!!!!
Jas
poster:jasmineneroli
thread:417092
URL: http://www.dr-bob.org/babble/20041118/msgs/418813.html