Posted by ed_uk on November 23, 2004, at 6:30:49
In reply to Re: Best choice SP med in the UK? MAOIs?, posted by Ted Brosnan on November 22, 2004, at 12:07:18
Hi Ted!
I'm glad to hear that you'll be getting an appointment. Unfortunately, no one will be able to tell you for sure whether the sexual side effects would go away after 2-4 months, the only way to find out would be to try the MAOI and see what happens!!
To be fair, neither Nardil nor Parnate has been well studied in ADHD but theoretically Parnate (tranylcypromine) might be better.
Here is a little study...
Arch Gen Psychiatry. 1985 Oct;42(10):962-6. Related Articles, Links
Treatment of hyperactive children with monoamine oxidase inhibitors. I. Clinical efficacy.Zametkin A, Rapoport JL, Murphy DL, Linnoila M, Ismond D.
Fourteen boys (mean age, 9.2 +/- 1.5 years) with Attention Deficit Disorder (ADD) With Hyperactivity were treated with dextroamphetamine sulfate or a monoamine oxidase inhibitor (MAOI) (six received clorgyline, eight received tranylcypromine sulfate) for four weeks each in a double-blind, cross-over study that included a two-week placebo washout between active drug periods. The MAOIs had immediate, clinically significant benefit and were clinically indistinguishable from dextroamphetamine. Most children responded to both stimulant and MAOI. These findings of equivalent efficacy of MAOIs in ADD are in contrast to our previous studies with neurotransmitter system selective agents, which showed only weak effects, and suggest that multiple neurotransmitter alterations may be required for stimulant drug effects in ADD. The immediate response to MAOIs indicates a different mechanism from that mediating antidepressant effect. The MAOIs may be useful alternate treatments in selected cases of ADD.
All the best...
Ed.
poster:ed_uk
thread:418891
URL: http://www.dr-bob.org/babble/20041123/msgs/419228.html