Posted by pablo1 on November 28, 2004, at 18:26:45
In reply to Re: neurotransmitter chart » pablo1, posted by Larry Hoover on November 28, 2004, at 17:49:56
OK so the high number means it takes more of the drug to attach to the receptors & the low numbered drugs are stronger. I wonder if this is relative to milligrams or relative to a 'typical recommended dose' which would be more meaningful. Probably it's in relation to milligrams though I'd guess so that's another thing that needs to be calculated to get anything meaningful.
I didn't see many options for norepenephrine, I used a search of 'adrenergenic%' and assume maybe I chose the correct term. Maybe it should have been '%adren%' to capture other possibilities.
Then you'd have to look up the seratonin effects & work a little formula to figure dosage and relative effect of the three (and others...) The chart I've been using is at http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html and it's very helpful but much simplified. It would be very doable to use the data on the above site and crunch it down into a really usable chart like the one I just mentioned only with real numbers that relate to a typical dose. Maybe add rows if the effects are different at different doses like amisulpride increases dopamine at low doses & blocks it at high doses. When I was going on effexor I wanted to know the effects of dopamine & norep. but the pharmacist was helpless to give any meaningful answers. Of course then each drug effects a different part of the brain more or less so it becomes terribly complicated. No wonder the pdocs just throw something at you & see if it works. Terribly complicated stuff.
>
> The tendency of any substance to occupy the binding site of a receptor or an enzyme is measured by its tendency to leave the active site, all on its own. The Ki is the concentration of that substance that is required for the receptor to be 50% occupied (at equilibrium, as many binding events are beginning as those that are ending), in the absence of the natural ligand (e.g. dopamine, for the dopamine receptor). The smaller that value for Ki, the higher its affinity must be, as 50% occupancy occurs at lower substrate concentrations.
poster:pablo1
thread:420713
URL: http://www.dr-bob.org/babble/20041128/msgs/421519.html