Posted by zeugma on November 30, 2004, at 16:49:11
In reply to Re: Straterra for Depression, posted by zeugma on November 30, 2004, at 16:06:30
I would say nortriptyline and Strattera have similar AD properties, but I think a metabolite forms in extensive metabolizers of CYP 2D6 (a majority of the population) which is responsible for the energy drain Strattera causes, and in some people (including me) it can bring on a full-scale anhedonic depression after long-term use.
Conceivably taking enough of a 2D6 inhibitor such as Prozac or paxil would alleviate this problem. But Prozac and Paxil are not IBS-friendly drugs, and I think it's unwise to take a drug for the sole purpose of mitigating a side effect from another drug, unless absolutely necessary. I am not going to mess with Paxil in the hope that it would make strattera more tolerable.
poster:zeugma
thread:422158
URL: http://www.dr-bob.org/babble/20041128/msgs/422490.html