Posted by TomG on December 11, 2004, at 17:58:54
In reply to Re: To Tom, posted by ed_uk on December 11, 2004, at 17:43:33
Ed,
Geodon does in fact cause sedation through the H1 histamine receptor. If you go to the online product insert at http://www.pfizer.com/download/uspi_geodon.pdf you will see that the somnolence observed with Geodon is thought to be from antagonism of H1 histamine receptor. Also check out this article which goes more in depth about sedation and AP's. http://www.psychiatrist.com/pcc/pccpdf/v06s02/v06s0201.pdf
But you may be right the sedation I'm experiencing might be via another mechanism but no research I've read points any other direction. But, I have to try something else. I'm OK on Geodon though. Its great for deep depression, anxiety, cognition, confusion, paranoia. The sedation I'm having is mimicking some negative symptoms of schizophrenia like anhedonia, amotivation, avolition. I know these symptoms are caused by the sedation and not a reemergence of symptoms from the disease itself. I'm about to seek out another AP, so if nothing else works I'll always have Geodon to fall back on. It has been a miracle drug for many of my main symptoms.
poster:TomG
thread:427750
URL: http://www.dr-bob.org/babble/20041211/msgs/427867.html