Posted by ed_uk on December 16, 2004, at 14:11:32
In reply to Re: Metyrapone May Be Effective as Additive Treatment, posted by SLS on December 16, 2004, at 13:56:54
Hi Scott,
Here's the monograph from the BNF...
METYRAPONE
Cautions: gross hypopituitarism (risk of precipitating acute adrenal failure); hypertension on long-term administration; hypothyroidism or hepatic impairment (delayed response); many drugs interfere with diagnostic estimation of steroids; avoid in porphyria
DRIVING. Drowsiness may affect the performance of skilled tasks (e.g. driving)
Contra-indications: adrenocortical insufficiency (see Cautions); pregnancy, breast-feeding
Side-effects: occasional nausea, vomiting, dizziness, headache, hypotension, sedation; rarely abdominal pain, allergic skin reactions, hypoadrenalism, hirsutism
Dose: differential diagnosis of ACTH-dependent Cushing's syndrome, 750 mg every 4 hours for 6 doses; child 15 mg/kg (minimum 250 mg) every 4 hours for 6 doses
Management of Cushing's syndrome, range 0.25–6 g daily, tailored to cortisol production.
Ed.
poster:ed_uk
thread:430050
URL: http://www.dr-bob.org/babble/20041211/msgs/430329.html