Posted by yxibow on December 17, 2004, at 1:59:36
In reply to Re: EPS from Cymbalta-yxibow?, posted by banga on December 15, 2004, at 17:42:44
> This was indeed a one-time, one-drug experience. This did not occur on SSRIs, Effexor, or clomipramine. I have been on short-term, not very high dose regimens of the newer antipsyxhotics, no big problems outside of fatigue and brain fog. The last time I took one (Geodon 40mg) was more than 2 months ago.
> When I tried to go up on Cymbalta, the symptoms increased. As soon as I dropped the Cymbalta, the symptoms stopped.
> I really think that the cymbalta for some reason simply interacts badly with my chemistry. I was surprised as I expected it to feel like a cleaned-up version of clomipramine, from which I had no side effects at all.I only asked about the AP because under some really unfortunate rare circumstances its cumulative and it shows up later with other drugs. I dont know how long you took the Geodon so I have no data there but I am just gathering you didnt take it for a very long period of time.
Well I again sympathize with your experience, it is obviously different with my experience, I have been on it near since its outset, as have countless people. There are no mentions in PubMed regarding it, but it is a new drug and with all new medications in vivo interactions will still come in. Not to be callous, but it is still possible that the severe anxiety you felt caused the motor disorder itself, even the jaw tightening, that is neither as unknown as Cymbalta causing it (and I'm neither a drug representative nor a doctor here).
I can certainly resonate with drugs reacting badly with chemistry.. a small trial of Zyprexa has left my hands, while better, ever so slightly tremorous inside just enough that I know I can "feel" them. That's something that you wont find in any annals of drug literature for a few weeks of olanzapine.
I would definately expect Cymbalta to be a "cleaned up" version of clomipramine, being a (arguably) 4th class modern antidepressant (tricyclics and MAOIs, SSRIs, Remeron and Effexor and Wellbutrin, etc). But YMMV. If Anafranil worked for you, then try it again... I know it has some nasty sweating problems and other things that trycyclics have. Those are the breaks. On the other hand Anafranil was the first OCD drug and some pop it in the SSRI category.
Perhaps you might want to try Lexapro or Celexa if you haven't already. But I dont know your dx. and dont pretend to be your doctor [insert standard double disclaimer]
Pleasant holidays and I hope things sort out for you
poster:yxibow
thread:423636
URL: http://www.dr-bob.org/babble/20041211/msgs/430638.html