Posted by ed_uk on December 21, 2004, at 18:08:04
Has anyone become sensitized to the effects of an amphetamine or methylphenidate?
Here is a little article which may be of interest..........
Biol Psychiatry. 1998 Dec 1;44(11):1171-7.
Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans.
Strakowski SM, Sax KW.
Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA.
BACKGROUND: Behavioral sensitization is the process whereby intermittent stimulant exposure produces a time-dependent, enduring, and progressive behavioral response. Although animal models of sensitization are well established, the phenomenon has been relatively little studied in humans. In a previous study, we reported enhanced responses following a second as compared to a first amphetamine dose in eye-blink rate and ratings of increased motor activity/energy, increased speech, and elevated mood in normal human volunteers. This current study extends those findings in a new sample of normal volunteers. METHODS: Eleven normal human volunteers were administered three single oral doses of d-amphetamine (0.25 mg/kg) at 48-hour intervals, alternating with matched placebo in a randomized, double-blind trial. Hourly behavioral ratings included eye-blink rate, symptoms (elevated mood, increased speech, increased motor activity/energy), and subjective drug effects. RESULTS: Eye-blink rate and increased motor activity/energy ratings progressively increased following each challenge with the third amphetamine dose response significantly greater than all other conditions 4 hours postadministration. Similar, although less pronounced, responses were observed for elevated mood and subjective drug effect. CONCLUSIONS: These results provide further evidence for sensitization of some amphetamine-induced behaviors in human subjects.
poster:ed_uk
thread:432577
URL: http://www.dr-bob.org/babble/20041217/msgs/432577.html