Posted by zeugma on December 21, 2004, at 18:34:31
In reply to Re: anyone taken TCA w/amphetamine?, posted by ed_uk on December 21, 2004, at 18:14:57
Hi Ed,
These reports suggest that MPH interacts with imipramine and probably other tertiary amine TCA's, but not desipramine, a mode substrate for CYP 2D6, nor nortriptyline, metabolized by the same pathways as DMI.
This is why my pdoc's first choice was to have me on Strattera, as even drastic elevations of atomoxetine plasma levels are not highly toxic, and then nortriptyline, rather than clomipramine, since CMI is similar to IMI in its propensity for interactions, including documented ones with Provigil, as well as concerns with MPH. That's why I have Lexapro samples on my kitchen table. presumably, Lexapro + nortriptyline would approximate the effect of clomipramine without the added danger of pharmacokinetic interactions with MPH or provigil.
There was nothing specifically about amphetamine in the reports. the anxiety from ritalin is starting to fade, and so am I (seven hours after my last dose of Ritalin LA). I tried to keep myself awake with caffeine, but find that i really can't drink the stuff with the same abandon. I suppose a drug that keeps me alert till about 6 or 7 pm isn't that bad, although I do feel constrained by this. (on the other hand, insomnia is worse.)
by the way, I'm male. but plain old 'zeugma' will do :)
-z
poster:zeugma
thread:432501
URL: http://www.dr-bob.org/babble/20041217/msgs/432594.html