Posted by KaraS on December 24, 2004, at 14:39:02
In reply to Re: Maprotiline + MAOI? » KaraS, posted by SLS on December 22, 2004, at 0:56:53
> > > If you are going to choose Parnate, it would be a good idea to monitor for a hypertensive reaction upon initiating treatment. This sometimes occurs as a startup effect, and is not dosage dependant. Symptoms of a reaction would include:
> > >
> > > • occipital headache which may radiate frontally
> > > • palpitation
> > > • neck stiffness or soreness
> > > • nausea or vomiting
> > > • sweating (sometimes with fever and sometimes with cold, clammy skin)
> > > • photophobia
> > > • either tachycardia or bradycardia
> > > • constricting chest pain
> > > • dilated pupils
> > >
> > >
> > > - Scott
> >
> > How common is it to have one of these start up effects from Parnate?
>
> Extremely uncommon. Maybe just short of rare?
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8399806
>
Thanks. I'd like to get ahold of that whole article. I'll have to do more research into it - though maybe this is one of those times where I'd be better off not doing any more research.
> > That list is enough to scare anyone to death.
>
> I know. However, I'm sure you've read enough drug monographs to understand that listings of side effects are always scary viewed with perspective.
Very true. (Why should the MAOIs be any different?)
> > What we go through just to feel normal!
>
> No sheet.
>
> > I have my doubts whether I'll be able to tolerate Parnate or Nardil. When I take dopaminergics, they put me to sleep at first and then in time they make me feel sick.
>
> I would not consider MAOIs as being "dopaminergic". They do not cause an artificial massive release of dopamine or inhibit its reuptake the way amphetamine and methylphenidate do respectively. Parnate, of course, can be stimulating. I don't know if the mechanism behind this effect has been fully elucidated, but it does not appear that there are any amphetamine like metabolites that would be responsible for it.Yes but it does make more dopamine available in the synapses (along with other neurotransmitters), no? I wonder if the stimulant effect isn't more similar to what the stimulating noradrenergic TCAs do? If that were the case, then I'd probably get tachycardia from it. (But then there's only one way to find that out.)
> > My head starts to feel like it's going to explode.
>
> That's just because you have packed too much information in your skull from all of the reading you have been doing. I wouldn't be surprised if it's leaking out your ears.:-)))
> > Or, maybe I'll just have to go really slowly and I'll have the same kind of experience that Todd had only probably more intense.
>
> What was this?
Todd felt tired and more depressed (don't know if there was any headache or feeling of increased pressure) at each dosage increase of Parnate for at least a week. He attributed this to the possible downregulating of dopamine autoreceptors.Kara
poster:KaraS
thread:431820
URL: http://www.dr-bob.org/babble/20041223/msgs/433798.html