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Re: Good finds, here's what I think » ed_uk

Posted by Michael Bell on January 6, 2005, at 20:19:49

In reply to Re: Me thinks this is very interesting indeed (long), posted by ed_uk on January 4, 2005, at 12:52:23

It seems that unrelated studies regarding unrelated medications (moclobemide, reboxetine, amitryptiline) have all found that coadministration of a noradrenaline reuptake inhibitor along with an MAOI negates the hypertensive crisis situation. I think reboxetine would be the most effective, since it acts only upon norepinephrine and binds to the NE transporter, blocking tyramine from doing so.

What does this all mean? Well, Reboxetine, AMitriptyline, etc. probably do greatly reduce the risk of hypertensive crisis, but it's not a 100% guarantee and a lot depends on the mixture of meds, length of time on it, etc.

Bottom line: Rebox and the others are probably great antihypertensive preventative meds. Question is, who has the guts to try it?

P.S. By the way, Reboxetine sucks as monotherapy for social phobia.


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