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Re: P450 Interactions?

Posted by jasmineneroli on January 12, 2005, at 1:29:21

In reply to Re: P450 Interactions? » zeugma, posted by jujube on January 11, 2005, at 23:45:40

Hi Tamara:
It's the dreaded CYP450 -2C19 that causes all my bad side effects!! I found this out after following an interesting thread here a few months ago.
The one common denominator between the drugs that gave me rotten (and identical) side effects was that they all were metabolized by 2C19.
I now avoid any drugs that require this liver enzyme to be processed. I'm either a slow metabolizer of 2C19 or lack the enzyme altogether.

As Zeugma says, Provigil will probably enhance the action of Celexa, if you're metabolizing Celexa OK. (Like no side effects, and a therapeutic effect at "usual" dosage").

Below is a useful link to a cyp450 table and various drug/food interactions and genetic deficiencies. So you can check them out. Unfortunately, it's a little out of date, so Citalopram and Provigil are not listed, but there's good info there anyway.
Larry H. knows of others.
Good wishes,
Jas

http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm#all


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poster:jasmineneroli thread:440448
URL: http://www.dr-bob.org/babble/20050108/msgs/440976.html