Posted by darkhorse on May 6, 2005, at 9:24:07
In reply to Re: Clomipramine + prozac = HELP:!! » temoigneur, posted by ed_uk on May 6, 2005, at 6:28:01
> Hi Ben!
>
> Prozac can produce very large increases in clomipramine serum levels. It will be necessary for you to reduce your clomipramine dose. If you continue to take 115mg clomipramine in combination with Prozac, your serum clomipramine level may continue to rise. If I were you, I'd reduce the clomipramine dose immediately, as little as 25mg a day might be sufficient- although you will definitely need to experiment. You could try taking 25mg or 50mg clomipramine for the next day or two. If you start to suffer from withdrawal symptoms you will know to increase the dose. If you still feel sedated or if other (clomipramine) side effects are present, you could reduce the dose even further.
>I agree with ED.
I have tried Prozac20 with Clomipramine 75mg and the side effects was too strong (tremor,sweating...)it was like taking 200-300mg of Clo.
Paxil and Prozac increase all TCA's very much.
I tried Prozac with imipramine and kept imipramine at 25mg and felt like it was 75mg.
I also tried Nortriptyline 25mg with Prozac 20 but the effects was very very strong. Nort 10 mg was still powerful...so take care mixing Prozac with Nort.
The least (for some reason) that P did not affect strongly were Amitriptyline and maprotiline.
P.S. Be very cautious when combinnig a TCA with Fluvoxamine(Luvox/Faverin) as it inhibits lots of enzymes except 2D6, so theoratically the safest TCA combo with Fluvoxamine would be Nort. and Desipramine.DH
poster:darkhorse
thread:494252
URL: http://www.dr-bob.org/babble/20050504/msgs/494465.html