Posted by BIGDaddyachmed69 on May 9, 2005, at 0:06:35
In reply to Re: Darned dyslexic fingers, Depakote, GHB and sleep, posted by cache-monkey on May 8, 2005, at 14:47:13
> << As far as falling asleep, that's definately not the problem...I experience significant fatigue throughout the day. It's staying asleep...I wake up every couple hours if I don't take a Lunesta. So maybe that's the Depakote, I dunno... >>
>
> Thanks for bringing up the dopamine rebound idea. That might explain some of my daily cycle in response to Depakote. I'm on the ER version and take my dose a couple of hours before bed. I tend to start feeling better and better around the time I take my dose, and that continues further for a while. I usually have trouble getting to sleep and staying asleep. I feel like I just sort of skim the surface of sleep the whole night. And wake up feeling like crap.
>
> The thing about the ER version is that my Depakote levels should be falling around dosing time. But the ER version kicks in slowly with the peak after a single dose occuring 4-17 hours later.
>
> If I'm at the longer end of that, I'd imagine my blood level to continue decline for a while after taking the dose. Upshot could be that I'm getting the dopamine rebound around the time that I'm trying to sleep.
>
> Maybe I'll switch to the non-ER version and see if that makes a difference...It's worth a shot. I probably forgot to mention I also take the extended-release version, but in the morning rather than at night. I used to take it at night, but had trouble falling asleep like you...at least I only have trouble staying asleep now (I guess).
poster:BIGDaddyachmed69
thread:494405
URL: http://www.dr-bob.org/babble/20050504/msgs/495409.html