Posted by ixus on May 21, 2005, at 2:57:22
In reply to Re: tranylcypromine versus phenelzine » ixus, posted by ed_uk on May 20, 2005, at 19:31:02
Hi Ed,
> This info might be useful. It's certainly very > interesting that MAOIs inhibit all those
> enzymes apary from MAO!!!
>Hydrazine and the acetylenic derivatives seem to oxidize MAO (flavin prosthetic group of MAO).
> The mechanism of action of the cyclopropylamine tranylcypromine is less certain but may involve initial formation of an imine by MAO, followed by reaction of a sulfhydryl group in the active center of the enzyme.
>
This article is consistent with what I read. There was some deeper explanation. I will try to find it.Thanks
/ixus
poster:ixus
thread:500450
URL: http://www.dr-bob.org/babble/20050516/msgs/500669.html