Posted by Elroy on May 24, 2005, at 14:26:05
In reply to Re: Urine Test to Measure Neurotransmitter Levels? » Elroy, posted by 4WD on May 23, 2005, at 22:12:36
BTW, here's some more information on how (elevated) cortisol can impact on one's brai neurotransmitters - and affect how they feel, anxiety levels, depression levels, etc....
QUOTE: Cortisol receptors exist on almost every cell in the body and have an important role in brain function. Cortisol may cause fatigue by depleting serotonn (5-HT) in the raphe nuclei, the area of the brain that normally activates the release of NE to increase vigilance. Moderate and transient amounts of cortisol increase the release of dopamine from this pleasure pathway as part of the reward cascade. High and chronic levels of cortisol decrease the production and release of dopamine – thus feelings of pleasure can be harder to produce. In this aspect stress can be a factor in depressive symptoms if either the levels of cortisol are too high or too low. Cortisol is the precursor to the anxiety reducing (anxiolytic) and GABA potentiating neurosteroid, 4-deoxycorticosterone. Cortisol also upregulates tyrosine hydroxylase, the rate limiting enzyme in the synthesis of catecholamines. Cortisol can also increase the transcription of PMNT phenyl-N-methyltransferase, the enzyme responsible for converting norepinephrine to epinephrine. As previously mentioned the upregulation of neurotransmitter function is tempered because cortisol also increases MAO (monoamine oxidase). END QUOTE
http://www.neurorelief.info/newsletterarchive.php?issue=460
Some others (may be repeats of ones earlier sent):
http://www.healthyplace.com/communities/depression/psychotic.asp
http://www2.eclinicalpsychiatrynews.com/scripts/om.dll/serve
http://www.pslgroup.com/dg/2030E2.htmElroy
X
X
X
X
XX
X
X
X
> > Arrrrgggghhhh.....
> >
> > RE: "My endo said that elevated cortisol does not make you feel differently... he is already assuming the tumor is not active. He said that even if it were, it would not be causing the level of depression and anxiety I described. "
> >
> > I cannot, absolutely cannot believe that an Endo actually said that!
> >
> > Have him go to the following web site:
> >
> > http://boards.cushings-interactive.com/invboard/index.php?act=idx
>
>
> Dear Elroy,
>
> Thank you so much. I have registered at the Cushings site and will read the postings you cited as soon as I get my confirmation email. I will print some out and take with me to my next appt. If the guy is still adamant I will find another endocrinologist.
>
> I am so relieved to know this terror and anxiety could be from the elevated cortisol. Part of what makes it so horrible is just not knowing why it's happening. I have been over every possible reason a million times. Now I have hope that there is an answer.
>
> I can't believe you took the time to look all that up for me. Truly, I am so grateful.
>
> Marsha
>
>
>
>
>
>
>
poster:Elroy
thread:493827
URL: http://www.dr-bob.org/babble/20050521/msgs/502280.html