Posted by Maxime on May 29, 2005, at 15:59:44
In reply to Re: I could really use an answer, posted by willyee on May 28, 2005, at 0:07:39
Thanks. I actually wrote to WebMD and asked them why they said it was reversible. Then I came across the following:
_____________________
Irreversible MAO-A and MAO-B Inhibitor (MAO-IA,IB)
The non-selective inhibition of both MAO-B and MAO-B produces an increase in the concentration
of serotonin, norepinephrine, and dopamine in the brain. The broad-spectrum boost in neurotransmitter
chemistry provides a powerful antidepressant e ect. It also provides for some of the negative
side e ects; this category of medications, like others that boost serotonin levels, tend to impair or
suppress libido and sexual function.
Tranylcypromine is most often described as an irreversible inhibitor of both MAO-A and MAOB,
although there are a few references which contradict this assertion and claim that it is reversible.
In any event, the washout times cited are more like those of irreversible MAO inhibitors, so it will
be considered irreversible here.
__________So I guess the jury is out on this one!
Thanks for posting about it. It's interesting.
Maxime
> > Where did you read this and what criteria did they use. I would like to read the article.
> >
> > Maxime
> >
> >
> > > Hey guys,
> > >
> > > I recently read that parnate is now considered a REVERSABLE MAOI.If this is the case,why would say taking Nardil in the morning and parnate hours thereafter,has im not suggesting this to anyone just curious if anyone might have exper this phenom.
> > >
> > > We write it off cause medically it seems deadly,and so it might be,but what if it isnt,i say this cause i mentioned time and again about having a great response to parnate the day after my nardil trial was cut.
> >
> >
>
> Its spread out in various sites on a google search this is on page one
>
> http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20P)/PARNATE.html
>
>
> Heres the snip its in the second paragraph:
>
>
> Tranylcypromine differs from other MAO inhibitors in being a reversible inhibitor. When tranylcypromine is withdrawn, monoamine oxidase activity is generally restored within a week, although the drug is excreted in 24 hours.
>
>
poster:Maxime
thread:503735
URL: http://www.dr-bob.org/babble/20050527/msgs/504822.html