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Re: CLOZARIL?

Posted by xbunny on June 10, 2005, at 5:10:03

In reply to CLOZARIL?, posted by TomG on June 9, 2005, at 21:23:10

Hi there,

> I guess maybe looking at the list I should try pushing the doses to the highest recommended, and I don't think I'm going to resort to the older typical AP's. I would welcome anything anyone has to say about Clozaril.

If I were you I would try the following:

a) push the doses of atypical antipsychotics you have tried harder, especially the risperdal .75mg isnt a working dose for sz. Since the geodon worked but gave anxiety try a lower dose or adding an anxiety drug. Similarly for the abilify.

b) try Solian/Amisulpride as far as I know this has a real proven record for the negative symptoms of sz. It worked really well in that respect for me but was next to useless against the positive symtoms. If I were suffering heavy negative symptoms again I would probably take it with a typical.

c) try several different typical antipsychotics, ie a sedating one, an alerting one, a low potency and a high potency. Despite the scare stories and jokes about the thorazine shuffle etc typical antipsychotics also have a proven record and I reckon you owe to yourself to at least try a few.
For me the high potency and alerting antipsychotic depixol/flupenthixol has been a god send, superior for both positive and negative symptoms more than any atypical I have tried.

d) try combining an antipsychotic with an antidepressant. According to my last CPN a good many of her sz clients take remeron/mirtazapine in conjunction with there antipsychotics with benefits to all. I also take it and its helps considerably.

e) then consider clozapine, theres nothing wrong with clozapine but really I reckon you should exhaust a lot more possibilities before taking it.

Just my .05$, Bunny


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