Posted by Nixon on August 13, 2005, at 20:38:08
In reply to Remeron for post-stroke depression, posted by ed_uk on August 13, 2005, at 9:20:19
> Mirtazapine for prevention and treatment of post-stroke depression in patients with
> acute stroke?
>
> Source J Clin Psychiatry. 2004 Dec;65(12):1619-23
>
> According to a report in the Journal of Clinical Psychiatry, mirtazapine, initiated on the first day after acute
> ischaemic stroke is effective in preventing the onset of depression.
> The study aimed to examine whether prophylactic treatment with the antidepressant mirtazapine in patients
> with acute stroke given from day 1 after the incidence prevents post-stroke depression.
> The study involved 70 patients with ischaemic stroke who received either 30 mg mirtazapine or no
> antidepressant medication from day 1 after the stroke in an open, randomised study design. Data were
> collected for a period of 17 months. Patients were re-examined on days 7, 44, 90, 180, 270, and 360 using
> neurologic, functional, and depression rating scales. Those post-stroke patients who developed depression
> (DSM-IV criteria) but had been randomly assigned to the nontreatment group were given the antidepressant
> mirtazapine after the diagnosis of depression had been established.
> According to the researchers, 40% (14/35) of the nontreated patients and 5.7% (2/35) of the patients who
> were treated with mirtazapine developed post-stroke depression. Fifteen of these remitted after initiation of
> treatment with mirtazapine. The authors estimate that mirtazapine use will prevent 34 cases of depression for
> every 100 stroke patients treated.Hi Ed!
Interesting study and I am not surprised. It seems that Remeron is getting a lot of positive results through clinical trials for a variey of disorders. Neurotransmitter.net has many interesting unrelated studies on Remeron. John
>
poster:Nixon
thread:541013
URL: http://www.dr-bob.org/babble/20050811/msgs/541289.html