Posted by SLS on August 28, 2005, at 13:28:55
In reply to Re: Keppra pharmacological properties - Shawn T.? » SLS, posted by Shawn. T. on August 28, 2005, at 11:25:57
> >Do you know of any bad ones?
>
> I tried looking through the literature, but I couldn't find any useful information.
>
> Shawn
Thanks for trying, Shawn. I really appreciate it.I was thinking that Keppra might affect terminal vesicles in a way similar to reserpine at first via SV2a receptors. This might account for the rapid antimanic effect sometimes seen with Keppra. Afterwards, the function of the vesicles might become reregulated in a manner similar to cell membranes in response to exposure to antidepressants. Perhaps this modulation would involve synergistic contributions by the modulation of N-type calcium channels that are required for vesicular release.
Just thinking out loud...
I wish this Keppra would give me some more hope to cling to. So far, I have not experienced a return of the antidepressant response I gleaned during the first week. I am not feeling worse, though. What I find significant, however, is that I went through a day of severe worsening of my condition after the initial improvement disappeared from which I recovered quickly. Again, I wonder if this wasn't a reserpine-like action of Keppra that caused a brief period of monoamine depletion before reregulation began to take place.
- Scott
poster:SLS
thread:545975
URL: http://www.dr-bob.org/babble/20050827/msgs/547629.html