Posted by SJW on August 29, 2005, at 15:55:47
In reply to Calling Scott (SLS) and Emme-you'll be interested » SJW, posted by ed_uk on August 29, 2005, at 7:30:20
Hi Ed,
thanks for the welcome.> What dose did you take and what side effects did you suffer? What other medications do you take?
It's been just over two years since I stopped the dextromethorphan cocktail. Let me preface this by saying that in hindsight my dosing schedule was irresponsible and dangerous... I found, for me, that 420mg dextromethorphan-polistirex was the minimum dose that had psychoactivity. At fisrt(about 3-4 days) the short-term memerory deficit was profound. I was already taking 20mg Adderall bid, 20mg famotidine bid, 2000mg Omegabrite(= approx 1250mg EPA & 550mg DHA) bid and 500mg niacinamide bid. I worked up to 600mg of dextromethorphan, then 720mg. When I hit 960mg(total remmision) my gait, then speech became noticably impaired and the urinary hesitancy was problematic. This is when I decided that I was doing more harm than good and ceased that protocol(after approx 4 wks in total). The negative effects luckily dissipated after 2-3 days and the antidepressant effect lasted approx 4-5 days.
I belive that MK-801,ketamine or PCP would have produced similar results, but that's pure speculation.
Also, on this regime I believe I felt a bit too good, slightly manic perhaps.
> Have you tried memantine and/or amantadine? - both NMDA antagonistsYes, both. It was a few months later. First memantine, up to 30mg bid, didn't have much effect with or without Adderall. After two weeks I added sertraline for its SSRI and sigma receptor activity. I quickly worked up to 200mg q.d., but nothing positive transpired.
Amantadine, first alone 100mg bid for about five days. Then 200mg and finally 300mg bid over the peroid of about 3-4 weeks. Again the effect was mild, somewhat stimulating in a basic kind of way.
The rebound depression it produced on some days was not basic in its nature however. The Adderall
and sertraline didn't help.I still have many more meds that I want to try.
Right now I take:
Parnate 40mg bid
Depakote 250mg bidI have a theory(ies) as to why some NMDA antagonists have profound antidepressant activity, but now it's a matter of finding something else alone or in combination that can safely affect the same pathway(s).
Steve
poster:SJW
thread:546159
URL: http://www.dr-bob.org/babble/20050827/msgs/548242.html