Posted by linkadge on August 31, 2005, at 7:58:53
In reply to Re: To Linkadge, posted by denise1966 on August 31, 2005, at 6:33:23
You have to let go of the serotonin transporter theory. As chairman_MAO said Nardil increases serotonin, but has no effect on the serotonin transporter. ECT also does not effect the serotonin transporter. Perhaps you mean the serotonin receptors.
When celexa worked. I spent years convincing myself that I had a bad serotonin gene. But then the drug stopped working, and I am actually doing better *off* drugs as they only make me feel worse.
Depression can totally change. I was on celexa, that worked but then stopped working. I swiched to another SSRI (same class) which worked.Ilene was just saying below that desipramine worked very well in the past when she was not under stress, but did't work in the future.
Another thing is that SSRI's can lower dopamine over time. That is why apathy sometimes sets in long after a drug was started. Sometimes the apathy responds to dose reductions of the SSRI. Brain chemistry is dependant on so many factors.
Depression can manifest itself in an entirely different way at different life stages, and so different drugs can be usefull.
My mother never drank coffee when she was 20 something cause it made her too jittery. But now that she doesn't work, she drinks it all the time! Whats up with that ?
Another reason why a particular drug may not work is because of the liver. Sometimes when a drug is taken for long periods of time the liver gets used to it an metabolizes it faster. (Ie metabolic tollerance to the drug.)
You've got to try *different* drugs, try TCA's try zoloft, prozac, TCA+SSRI combinations be creative.
Have you tried clomipramine ??
Linkadge
poster:linkadge
thread:548105
URL: http://www.dr-bob.org/babble/20050827/msgs/549131.html