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SSRI-induced apathy - how long to clear?

Posted by Laurie Beth on September 5, 2005, at 23:44:40

I am experiencing post-partum apathy and anhedonia that I hope (based on a prior experience a few years ago when I was on 300 mg of Zoloft for several years) is caused largely by being on high dose of Zoloft (dose increased prophylactically on day I gave birth, from 40 mg to 100, then 200 mg). Over the past two months, I have been slowly tapering off the Zoloft - was at 50 mg a month ago, now at 6 mg, will be off completely in 2 days. As I've decreased, I've experienced less sleepiness and maybe 25% less apathy and anhedonia (varies from day to day in no pattern that I can discern), but I'm crossing my fingers that eventually I will feel much better, that, this time around, it really is my drug that is my problem.

If the Zoloft is actually causing these apathy and anhedonia, how long might I expect to keep seeing improvement after going off completely? I did see at least one case report in which the woman's apathy resolved completely 1 month after going off the SSRI. I know that the Zoloft should be out of my brain within 16 days after stopping (according to pdoc, anyway), but I imagine that other cascading effects (dopamine increase?) might take much longer.

Any experiences? Or even speculation?

Thank you.


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poster:Laurie Beth thread:551254
URL: http://www.dr-bob.org/babble/20050901/msgs/551254.html