Posted by needesp on September 7, 2005, at 20:04:37
I introduced myself earlier with concerns about my son's usage of MJ (Marijuana and antidepresants). He has been on Effexor 300mgs and Avanza (mirtazipine) 60mgs for 13 weeks and just recently (10 days ago today) been put up to Effexor 375mgs as his OCD had worsened and depression resurfaced. The mix in this equation is Marijuana which he started when he left the clinic at the 4 week mark on the higher doses.
HIs MJ use has increased over the last 10 weeks (now at 3 to 4 gms of MJ a night) and just recenty in the afternoons he has become very anxious/agitated just prior to starting his MJ at 5pm (the last couple of nights he has taken 100 mgs of Seroquel to relieve the agitation - the MJ wasn't getting him stoned - i thought that it might be due to the higher dose of Effexor). With the seroquel he was able to relax (OCD slow down) and get stoned again on the MJ!)
His mood is muted most of the time and he has lost interest in things (he gets to things he has to i.e. trainer x 2 week and his day clinic x 1 a week but his motivation is low and he isn't getting pleasure in them and afterwards i.e. when he returns (around the time of starting MJ) he is very negative/OCD running and this leads to agitation (he has had 6 bouts of intense anger in last 4 weeks)
I kept thinking that if the medication combo would work his desire for MJ would reduce. Must admit though that the increase to Effexor 375mgs (10 days now) has just today shown signs of impovement as he has woken without any depression, the first day of relief again in over 3 weeks).
Could you tell me how the MJ would work alongside of the Effexor and Avanza (I.e. neurotransmitters) and how Seroquel added to the equation works. Basically whats going on in his brain chemical scenario daily i.e.
Effexor 375mgs
Avanza 60mgs
Seroquel 100mgs
Marijuana 3gmsHe was told to use the Seroquel prn for agitation(100mgs a pop but only once a day and preferably to not use it eventually) but by the time he is agitated its all over bar the shouting (literally) as it takes about an hour to work.
I wondered if a steady dose of Seroquel in the evening would help? The time of concern is in the late arvo so I guess the seroquel would have been metabolised by then but is it like AD's and after a while the blood plasma levels stay up or would it need an am dose to keep him stable at 5pm.
Would so appreciate your knowledgeable input.
poster:needesp
thread:552017
URL: http://www.dr-bob.org/babble/20050901/msgs/552017.html