Posted by Chairman_MAO on September 8, 2005, at 23:31:34
In reply to Re: Maoi augment attempt, posted by Declan on August 21, 2005, at 19:16:32
Nardil is working really well, except for one thing: sexual side effects galore. Arousal and orgasm affected severely, and sometimes my libido is dampened. However, given that I am 25 and taking dodder seed extract, epimedium, tribulus, and shilajit, the libido is adequate anyway.
I see my doctor tomorrow, and I am going to beg him to fix this problem. I have done an extensive amount of research, and I currently feel that a combination of a dopaminergic agent and bethanechol/neostigmine/etc (cholinergic/parasympathomimeticO will probably work. I have no idea why my initial spectacular success with cabergoline faded into nothingness; perhaps it is simply because I started it early in my nardil treatment, and now the sexual difficulties are primarily caused by a non-dopaminergic mechanism.
I actually have been thinking about trying wellbutrin with nardil, thinking perhaps Nardil's massive SE and GABA increase will counterbalance the extreme agitation it used to cause me. I am not optimistic about this, however; I have tried wellbutrin several times in the past, and always found it somewhat dysphoric, even on 40mg of Valium/day. Perhaps the phenelzine will change that though; hell, I can tolerate yohimbine now, and I could not before. I wish I could just take a little dextroamphetamine bid-tid, but I had a drug problem at one point in time and once they slap that label onto you, it's bye-bye benzos, stimulants, and effective sleep medications-even if the drug problem was an attempt to deal with the mental illnes and no longer there!
Another thing I'm looking into trying is either testosterone cream or testosterone propionate injections (125-250mg/wk). Too bad I'll have to get the latter from a PhD organic chem friend of mine instead of via Rx (most doctors won't tell you this but testosterone is basically THE antidote to most sexual dysfunctions, male or female).
Wilyee: I am glad you are having success with parnate + Nardil. Personally, I have always figured the combination would be extremely effective. Good max dosage levels to try would be 0.5mg/kg Nardil + 0.35mg/kg Parnate. Nardil's halflife is quite a bit longer than Parnate's, IIRC, so you do not have to dose it as often. Twice daily could do it, three times daily definitely. I have no idea why more doctors do not combine the two; Nardil's GABA transaminase inhibition balances out Parnate's stimulation very nicely. However, it may also alter the activity of phenelzine because I think one study in some rodent species showed that one or more (I forget which) phenelzine metabolitse were not formed if MAO-B was inhibited. If your anxiety ist aken care of by 15mg nardil on top of it, tho, that should work out ok.
I am VERY surprised that cabergoline killed your libido. That is HIGHLY atypical, to the point that I wonder if there isn't something endocrinologically awry with you. I am not saying that you should be alarmed, and I don't know it all, that's for sure, but I just don't see how that could kill libido.
My meds:
90mg Nardil (30mg tid)
16mg buprenorphine p.o. qhs
50mg hydrochlorothiazide po (if I don't take this I gain 7+lbs in water from the Nardil)Does ANYONE have experience with ANY antidotes to Nardil's sexually crippling effects that actually WORK? Even _60mg_ of Cialis on top of cabergoline with all the herbs I am taking did not work. alpha-Yohimbine + cialis + herbs works somewhat, but I hate yohimbine's side effects.
So, if anyone can suggest what to ask my doc for tomorrow, PLEASE, let me know!!!
Thanks!
poster:Chairman_MAO
thread:544119
URL: http://www.dr-bob.org/babble/20050901/msgs/552525.html