Posted by neuroman on September 15, 2005, at 21:10:13
In reply to Re: Provigil, Ritalin sinus infections HELP! » Leonard Peabody, posted by florence on September 14, 2005, at 20:01:01
Hi,
This is an interesting thread. I've suffered with chronic nasal congestion for so long I had forgotten it was a problem. While i haven't had ear pain, i often get a staticy buzzing sound in my left ear. I have anhedonia and dysthimia and some anxiety. I also have chronic neuropathic pain. I figured i'd give bupropion SR a try because i'm certain low dopamine and/or norepinephrine is at the root of my problem. SSRI's haven't helped me. Anyway, with the first dose i found the bupSR relieved a lot of pain. Then over the course of the next few days i felt something going on with my sinuses and ears. They felt like they were clearing up. I actually found that i could sing along with the car radio without my nose getting stuffed up as it usually does. Unfortunately, the bupropion starting knocking me out for some reason so after a couple of weeks i stopped. I still have a bunch and plan on giving it another shot. I found out that besides being an NRI and mild DRI bupropion is also an alpha-2 agonist. Before i try it again i'd like to give a specific alpha-2 agonist like clonidine or guanfacine a try. They have also shown promise as treatments for ADD/ADHD so they must have some type of dopaminergic effect. I may give Ritalin a try also. Anyway, here are a couple of interesting norepinephrine links.
http://www.answers.com/topic/norepinephrine
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7507588&query_hl=7
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12387934&query_hl=16
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11777250&query_hl=16I've also read about people who have a deficiency of dopamine beta hydoxylase. This is the enzyme that converts dopamine into norepinephrine. These people have high plasma dopamine levels and virtually zero norepinephrine. The sypmtom complex consists of ptosis(droopy eyelids), orthostatic hypotension, low body temperature, a few other things and of course...chronic nasal congestion! I guess a similar symptom complex could occur if you don't have enough dopamine to convert to norepinephrine regardless of the amount of converting enzyme. I think this might be my problem. I hope this was of some help to you. Good luck...
Paul
poster:neuroman
thread:546314
URL: http://www.dr-bob.org/babble/20050914/msgs/555446.html