Posted by SLS on September 20, 2005, at 23:12:03
In reply to Re: Caffeine Partially Counteracts Sedationfrom Ambien » SLS, posted by jrbecker on September 20, 2005, at 13:39:10
Hi JB.
> > Speaking of orexin, I recently read something that suggested orexinergic activity might be partially responsible for the experience of reward and reward-seeking behavior. I wish I could remember where I saw it. Perhaps it is through orexin that modafinil produces its antidepressant effects, and not through glutamate. Maybe manipulating orexin would help in the treatment of substance abuse.
> You're probably referring to this...
> http://www.sciencedaily.com/releases/2005/08/050827140339.htmNo, I hadn't seen this article. I was just guessing at the substance abuse stuff.
> Sanofi's got a few orexin antagonists in preclinical trials. Of course, realize these are drugs that will inhibit the effect orexin has on pleasure. Might be good for drug withdrawal but not treatment-resistant depression.
From the article:
"Using rPP, a neuropeptide that activates orexin neurons in the lateral hypothalamus, the researchers were able to reinstate drug seeking in the rats formerly possessing extinguished drug-seeking behavior."
Might this peptide prevent or reverse learned helplessness, thus indicating antidepressant properties?
Would you happen to know if there is any connection between orexin/hypocretin and HPA axis activity? Perhaps chronic low orexin leads to increased HPA activity and increased cortisol production? I'm really reaching on this one.
- Scott
poster:SLS
thread:557238
URL: http://www.dr-bob.org/babble/20050914/msgs/557537.html