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Re: Questions about Abilify-SLS, Anyone

Posted by med_empowered on October 15, 2005, at 17:52:01

In reply to Re: Questions about Abilify-SLS, Anyone » SLS, posted by theo on October 15, 2005, at 16:04:43

hey! The tardive dyskinesia risk is higher with older meds, especially haldol and thorazine (around 3%/year baseline; higher risks for women, children, and elderly...at 5 years, about 20%; after long-term exposure, over 50%). The only med I've seen any good numbers on for TD is zyprexa, where the risk is estimated to be about .5-1%/year, but no one really knows for sure quite yet. Risperdal is believed by some to be the harshest atypical, and also the one most likely to cause EPS and TD..there have been a couple risperdal lawsuits regarding TD in those cases. Abilify is really new, so we won't know for a while how likely it is to cause TD...interestingly enough, it can be used as a treatment for pre-existing TD; the antagonist/agonist action apparently helps keep involuntary movements at a minimum. The therapeutic dose used to be considered 15mgs (this is for bipolar and schizophrenia), but now 10mgs is believed to be effective, too...your risk should be lower than that of someone taking the full, therapeutic dose (although one must keep in mind that people with mood-disorders are more likely to develop TD than are people with schizophrenia). Good luck!


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