Posted by ed_uk on October 25, 2005, at 16:29:44
In reply to Re: Antipsychotic [side] effects?, posted by silmarilone on October 25, 2005, at 15:52:11
Hi S,
>Bipolar disorder
Perphenazine can treat mania. In general, it doesn't relieve depression - and has a tendency to make it worse.
>Trilafon, according to my doc falls in the "medium" potency category...
Semantics........
IMHO, perphenazine is really very similar to haloperidol (Haldol) ...but it (perphenazine) does tend to be a bit more sedating. Haloperidol has the advantage of being a more thorougly studied drug. Partly due to the tendency of pdocs to prescribe vastly excessive doses, haloperidol has achieved a particularly infamous reputation. Such high doses can cause horrendous side effects. At equivalent doses, perphenazine and haloperidol would be expected to have a similar incidence of side effects. 8 mg perphenazine is comparable to about 2.5 mg haloperidol.
>I'm taking 8mg per day, bid
I think you should reduce the dose. I'd recommend trying 2mg twice a day. 2mg bid might sound too low - but it probably isn't. Traditional doses of perphenazine were generally excessive.
>Abilify caused EXTREME akithisia and anxiety, and insomnia...
What dose did you try? Have you tried Geodon?
>I decided to try the trilafon after hearing about the study where they said it was just as effective as atypicals and with fewer side effects in low doses...
The problem with perphenazine (and haloperidol) is the high incidence of tardive dyskinesia following long-term use.
Kind regards
~Ed
poster:ed_uk
thread:571572
URL: http://www.dr-bob.org/babble/20051024/msgs/571787.html