Posted by blueberry on October 27, 2005, at 17:28:59
In reply to DOPAMINERGIC SUPERSENTIVITY: what is the meanig?, posted by neo on October 26, 2005, at 13:42:15
I know what you mean about early amisulpride tolerance setting in. A few years ago I tried it and got a nice dopamine rush for a couple days, which then faded away quickly. But I kept taking it anyway at 50mg. About 3 or 4 weeks later, I noticed I was becoming comfortable around people, relaxed, interested in things, non-depressed, and just feeling a lot better in general.
It's like that initial dopamine rush caused quick tolerance kind of like what would happen if taking a stimulant. But then over time, the extra dopamine floating around caused other changes in the brain that resulted in gradual overall improvements that were independent and separate from the initial dopamine rush of the first couple days.
poster:blueberry
thread:572106
URL: http://www.dr-bob.org/babble/20051024/msgs/572464.html