Posted by emme on October 30, 2005, at 21:41:02
In reply to Re: SLS - how's the trial? » emme, posted by SLS on October 29, 2005, at 13:01:27
Hi Scott,
> I've discussed it with my doctor, but we had set > mifepristone as the priority.
My pdoc was interested in the idea of trying mifepristone, but hasn't pursued it aggressively at the moment. She did contact colleagues in Canada who have some experience with it. For now, she seems to have decided to work with a local endo and other cortisol drugs.
> Still, it would be interesting to see how
> ketaconazole or metyrapone would treat me.Would they be worth trying if mifepristone doesn't work? Or would they be weaker agents in comparison to mifepristone? Here's hoping you won't need to ask that question!
> > I spoke with an endocrinologist this summer who may try to treat some of my pdoc's treatment-resistant patients with cortisol-lowering drugs.
>
> Do you know which ones? Would he be combining different drugs?As far as I could tell, he was thinking of small doses of one drug. I think ketoconazole was a possibility.
> How well are you doing with the Abilify? Are you currently satisfied with the degree of antidepressant response?
I was blown away at first. Actually, I was too stimulated and felt hypomanic. Then I stopped being blown away. I think one thing that's happened is that the drugs we've tried to deal with the awful insomnia may have worsened my mood. I've had some nasty setbacks. My guess is that the AD effect of abilify is still there but was counteracted for a while.
So the current status is that I think both the memantine and abilify are good, but as usual, I'm limited by tolerance issues.
> How long have you been on Abilify? Are you taking at least 5.0mg?
No. 2.5 mg every other day. I'm reluctant to increase it until the insomnia is improved enough and I'm sure I won't be completely overstimulated. Actually, on a practical note, I may find it hard to afford a higher dose.
> I have had this happen a number of times when first starting Parnate or after adding a tricyclic.
Celexa did that to me even at 2 mg. It was ridiculous. I wonder how many people are frozen by their meds.
> > Last time I tried abilify, you suggested that it might be acting in a similar manner to apomorphine.
>
> If for some stupid reason, I were right,Hey, you never know. :) Someone's gotta be right - it might as well be you.
> it might indicate that you need to increase the dosage of Abilify, not lower it. It depends on whether or not there is a pronounced preference for its acting as a presynaptic DA agonist at low dosages.
In that case, it would be interesting to see what happens if I do try a higher dose.
> No answers, just more questions...But good questions. Thanks for the input. Keep us posted about the post-dexamethasone results.
emme
poster:emme
thread:572867
URL: http://www.dr-bob.org/babble/20051024/msgs/573603.html