Posted by zeugma on November 6, 2005, at 8:28:30
In reply to Re: VASOSPASM in psych/neuro disorders?, posted by linkadge on November 5, 2005, at 19:17:16
> Yeah, most of the models I have read about, involve hyper-noradrenergic and hypo-dopaminergic function in the frontal cortex.
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> Norepinephrine may increase alertness, but not focus. I don't know exactly.
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> LinkadgeNorepinephrine improves, roughly speaking, where your attention goes: to inner or outer experience? The locus coeruleus fires rapidly when a novel stimulus is presented, but then slows when an animal is directing attention to itself, e.g. when it is grooming itself.
Dopamine contibutes focus and degree to which you are awake. it is highly involved in perception. I can discriminate colors on high doses of Ritalin, but can't see them at all on anything else.
On Strattera I was able to direct attention to the outside world. That is how it helps inattentive ADHD IMO. You don't become as lost in your own thoughts.
Spontaneously hypertensive rats are an interesting animal model. They have peculiar responses to many drugs, not just ADHD-like symptoms.
-z
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poster:zeugma
thread:575565
URL: http://www.dr-bob.org/babble/20051106/msgs/575916.html