Posted by med_empowered on November 6, 2005, at 19:07:56
In reply to Is perphenazine anything like zyprexa, posted by Sebastian on November 6, 2005, at 11:08:31
hey! if i remember correctly from the CATIE study, perphenazine tends to cause more EPS than zyprexa (although its not too bad at lower doses). But...its more or less weight neutral, which is nice. It also has fewer effects (good or bad) on mood than zyprexa, which tends to be a mild antidepressant when used alone, and a more potent antidepressant when coupled with an antidepressant. (That said...low-dose perphenazine has been used pretty successfully as an add-on to antidepressants; its just a good idea to discontinue the medication QUICKLY). The TD risk I imagine would be higher than Zyprexa's; the standard rate for old-school neuroleptics is prolly 3%/year, maybe more (a lot of the studies under-estimated the TD rate). Zyprexa is about .5-1% annually. Long-term...after 5 years, 20-30% of people on old-school antipsychotics get TD; after very long administration, the number jumps over 40-50%. Have you thought about Molindone? Like I said, I dont like antipsychotics, especially old ones but...Molindone works differently from the other old ones, and is sometimes considered an atypical AP. It causes EPS, but apparently some researchers think the TD risk is pretty small.
poster:med_empowered
thread:575976
URL: http://www.dr-bob.org/babble/20051106/msgs/576116.html